Adewole O.S.

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Adewole
Olarinde Stephen
Dr
MBBS, MSc, PhD
stephenadewole@yahoo.co.uk
Department of Anatomy and Cell Biology
Faculty of Basic Medical Sciences
Research Interest(s): 
Endocrinology
Immunohistochemistry
Transmission Electron Microscopy

Dr Adewole contributed effectively, in various capacities, to the academic, social and general growth of the Department of Anatomy and Cell Biology, the University and the community at large. He developed research projects in the areas of experimentally-induced diabetes mellitus in laboratory animals. He initiated collaborations between the department and Optics and Imaging Centre, Doris Duke Medical Research institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa after his Post-Doctoral Fellowship programmes in South Africa in 2006. This collaboration emanated in the signing of Memorandom of Understanding (MoU) between Obafemi Awolowo University and University of KwaZulu-Natal, Durban, South Africa.

Dr Adewole’s research focus has been in markers of oxidative stress evaluating the ameliorative effects of plant extracts and drugs on stressful tissues. Oxidative stress have been implicated in the etiology of numerous common diseases especially diabetes mellitus. As anatomists, the use of electron microscopy, histological, histochemical, and immunohistochemical techniques have given us better understanding of pathogenicity of diabetes mellitus and its effects on the microanatomy of various organs in the body and we are able to monitor the ameliorative effects of these herbal products administered. The study of direct effect of chronic hyperglycemia on pro-oxidant and antioxidant biomolecules such as MDA, ROS, NO,  MnSOD, GSH-Px, H2O2, GSH/GSSG, Mitochondrial complex II, III, IV, and V, carbonyls and thiols have broaden our knowledge of pathology of diabetes mellitus.

Dr Adewole’s laboratory currently focuses on the enrichment of mitochondria antioxidants, consequently, therapeutic strategies to decrease ROS production, or to intercept the ROS once formed should be explored. Two approaches suggest themselves: selective uncoupling of mitochondria, and anticonvulsants.

Selected Publication(s): 
Adewole O. S., Adenowo T. K., Naicker T. and Ojewole J. A. O. (2011): Hypoglycaemic and Hypotensive effects of Ficus Exasperata Vahl. (Moraceae) Leaf Aqueous Extract in Rats. Afr J Trad CAM. 8(3): 275-283.